초음파 리프팅(MFU-V)은 처짐과 탄력 개선에 도움이 될까? 42개 연구 종합 분석

Abstract Microfocused ultrasound with visualization (MFU-V) is an advanced, noninvasive cosmetic procedure widely performed for skin lifting and tightening. We performed a systematic review and meta-analysis to evaluate the aesthetic effectiveness, patient satisfaction, skin quality, and safety profile of MFU-V treatment. A comprehensive search of 5 bibliographic databases up to 2023 was conducted. Pooled effect estimates with random effects models and corresponding 95% confidence intervals were calculated. Out of 4019 references, 42 studies were included. Meta-analysis showed 89% of patients (95% CI: 81%-94%; I 2 : 63%, n = 411) demonstrated some degree of global aesthetic improvement, as assessed by investigators. Similarly, 84% of patients (95% CI: 73%-91%; I 2 : 64%, n = 312) reported improvement following treatment. Satisfaction of any level was reported by 84% of patients (95% CI: 61%-94%; I²: 52%, n = 326), and 62% (95% CI: 37%-82%; I²: 3%, n = 172) when “neutral” as a response option was provided for patients. Skin quality (eg, wrinkles, texture) also improved. Patients reported a pooled mean pain score of 4.85 (95% CI: 4.35, 5.35; I 2 : 97%, n = 785), indicating moderate pain. Common adverse events included erythema, edema, swelling, bruising, and tenderness, all of which were generally mild to moderate in severity. Overall, our analysis demonstrated a notable increase in global aesthetic improvement and patient satisfaction following MFU-V treatment, accompanied by moderate pain and a generally favorable safety profile. However, the potential misclassification of neutral responses as positive may result in an overestimation of the treatment's efficacy. These findings highlight the need for well-designed trials to further explore MFU-V's clinical applications. Level of Evidence: 3 (Therapeutic)

CONCLUSIONS Our analysis demonstrated an enhancement in global aesthetic score and patient satisfaction, accompanied by a moderate pain score, following MFU-V treatment. The evidence showed that skin quality parameters aligned with these outcomes and suggested a generally favorable safety profile. However, future studies should address the gaps identified in the current research, including the role of participant characteristics, confounders, and variability in assessment tools. Well-designed, controlled trials are needed to further explore MFU-V's efficacy and safety, with attention to these factors to refine and optimize its clinical applications.